Dermal & Cosmetic Research

Melanotan II

Cyclic α-MSH analogue

Also known as MT-2, MT-II, Ac-Nle-cyclo[Asp-His-D-Phe-Arg-Trp-Lys]-NH2.

A cyclic heptapeptide melanocortin analogue used as a non-selective melanocortin-receptor agonist in pigmentation and receptor-pharmacology studies.

Current lot: SN-MT2-2608
Purity: 99.36% by HPLC
Tested: Aug 4, 2026
Stocked in: United States, Canada

Synamino Sciences research vial with a silver cap on a teal background

Ships from

Vial size

$32.00

USD · 10 mg · In stock

Qty

Order by 2:00 PM PT for same-day dispatch from Reno, Nevada. 1–3 business days by USPS Priority and UPS. Free shipping over $150.00.

For laboratory research use only. Not for human or veterinary use.

About the compound

Melanotan II is a lactam-bridged cyclic analogue of α-MSH. Its cyclic structure gives it broad activity across melanocortin receptor subtypes, which is why it appears frequently in receptor-selectivity and pigmentation research.

Supplied as a lyophilized powder.

Studied inMelanocortin receptors · Pigmentation · Receptor selectivity

Certificate of analysis

The certificate for the lot currently shipping. Every vial in that lot carries the same lot number on its label.

Certificate of analysis

Melanotan II · 10 mg

Lot SN-MT2-2608 · tested Aug 4, 2026

99.36%

Purity by HPLC

Labeled: 10 mg
Measured: 10.4 mg
Panel: 6 passed · 2 reported
Laboratory: Independent ISO/IEC 17025 accredited laboratory

Assay	Method	Result	Outcome
Appearance	Visual	White lyophilized powder	Pass
Purity	HPLC · spec ≥ 98%	99.36%	Pass
Net peptide content	HPLC	10.4 mg	Reported
Identity	LC-MS	Confirmed	Pass
Heavy metals	ICP-MS	Not detected	Pass
Sterility	USP <71>	No growth	Pass
Endotoxin	LAL · USP <85>	< 0.05 EU/mL	Reported
Residual solvents	GC-HS	Within limits	Pass

Specification and storage

CAS number: 121062-08-6
Molecular formula: C50H69N15O9
Molecular weight: 1024.2 g/mol
Residues: 7
Sequence: Ac-Nle-cyclo[Asp-His-D-Phe-Arg-Trp-Lys]-NH2
Reference record: PubChem entry

Storage

Sealed lyophilized vials are stable at room temperature for short periods; store at 2–8 °C for routine use.
For long-term storage keep sealed vials at −20 °C, protected from light and moisture.
Reconstituted solutions should be refrigerated at 2–8 °C and used within the period defined by your laboratory's protocol.

Literature

Peer-reviewed publications on this compound. Provided for reference; they are not claims about this product.

01
Life Sciences · 1996
Evaluation of melanotan-II, a superpotent cyclic melanotropic peptide in a pilot phase-I clinical study
Dorr RT, Lines R, Levine N, et al.
02
Pharmacology, Biochemistry, and Behavior · 2006
The melanocortin agonist, melanotan II, enhances proceptive sexual behaviors in the female rat
Rössler AS, Pfaus JG, Kia HK, et al.

Studied alongside

Melanotan I
Afamelanotide · α-MSH analogue
from $35.00
PT-141
Bremelanotide · MC4R agonist
from $34.00

Research notice

Melanotan II is supplied for in vitro laboratory research and analytical use by qualified professionals. It is not a medicine, supplement or cosmetic, has not been evaluated by any regulator, and is not for human or veterinary use. Published findings cited on this page are provided for reference and are not claims about this product.