Metabolic Research

MOTS-c

Mitochondrial-derived peptide

Also known as Mitochondrial ORF of the 12S rRNA type-c.

A 16-residue peptide encoded within the mitochondrial 12S rRNA gene, studied in AMPK signalling, insulin sensitivity and exercise-physiology models.

Current lot: SN-MOT-2607
Purity: 99.53% by HPLC
Tested: Jul 19, 2026
Stocked in: United States, Canada, Australia

Synamino Sciences research vial with a silver cap on a navy background

Ships from

Vial size

$42.00

USD · 10 mg · In stock

Qty

Order by 2:00 PM PT for same-day dispatch from Reno, Nevada. 1–3 business days by USPS Priority and UPS. Free shipping over $150.00.

For laboratory research use only. Not for human or veterinary use.

About the compound

MOTS-c belongs to the family of mitochondrial-derived peptides translated from short open reading frames in mitochondrial DNA. Research interest centres on its role in metabolic regulation and cellular stress responses.

Supplied as a lyophilized powder.

Studied inAMPK signalling · Insulin sensitivity models · Mitochondrial biology

Certificate of analysis

The certificate for the lot currently shipping. Every vial in that lot carries the same lot number on its label.

Certificate of analysis

MOTS-c · 10 mg

Lot SN-MOT-2607 · tested Jul 19, 2026

99.53%

Purity by HPLC

Labeled: 10 mg
Measured: 10.3 mg
Panel: 6 passed · 2 reported
Laboratory: Independent ISO/IEC 17025 accredited laboratory

Assay	Method	Result	Outcome
Appearance	Visual	White lyophilized powder	Pass
Purity	HPLC · spec ≥ 98%	99.53%	Pass
Net peptide content	HPLC	10.3 mg	Reported
Identity	LC-MS	Confirmed	Pass
Heavy metals	ICP-MS	Not detected	Pass
Sterility	USP <71>	No growth	Pass
Endotoxin	LAL · USP <85>	< 0.05 EU/mL	Reported
Residual solvents	GC-HS	Within limits	Pass

Specification and storage

CAS number: 1627580-64-6
Molecular formula: C101H152N28O22S2
Molecular weight: 2174.6 g/mol
Residues: 16
Sequence: MRWQEMGYIFYPRKLR
Reference record: PubChem entry

Storage

Sealed lyophilized vials are stable at room temperature for short periods; store at 2–8 °C for routine use.
For long-term storage keep sealed vials at −20 °C, protected from light and moisture.
Reconstituted solutions should be refrigerated at 2–8 °C and used within the period defined by your laboratory's protocol.

Literature

Peer-reviewed publications on this compound. Provided for reference; they are not claims about this product.

01
Cell Metabolism · 2015
The mitochondrial-derived peptide MOTS-c promotes metabolic homeostasis and reduces obesity and insulin resistance
Lee C, Zeng J, Drew BG, et al.
02
Free Radical Biology and Medicine · 2016
MOTS-c: A novel mitochondrial-derived peptide regulating muscle and fat metabolism
Lee C, Kim KH, Cohen P
03
Aging Cell · 2015
The mitochondrial-derived peptide MOTS-c: a player in exceptional longevity?
Fuku N, Pareja-Galeano H, Zempo H, et al.

Studied alongside

Humanin
Mitochondrial-derived peptide
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SS-31
Elamipretide · mitochondria-targeting tetrapeptide
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NAD+
Nicotinamide adenine dinucleotide
from $52.00

Research notice

MOTS-c is supplied for in vitro laboratory research and analytical use by qualified professionals. It is not a medicine, supplement or cosmetic, has not been evaluated by any regulator, and is not for human or veterinary use. Published findings cited on this page are provided for reference and are not claims about this product.