Metabolic Research

Semaglutide

GLP-1 receptor agonist

Also known as NN9535.

A GLP-1 analogue with an Aib8 substitution and a C18 fatty-diacid side chain, used as the reference long-acting GLP-1 agonist in receptor and metabolic studies.

Current lot: SN-SEM-2607
Purity: 99.38% by HPLC
Tested: Jul 25, 2026
Stocked in: United States, Canada, Australia

Synamino Sciences research vial with a silver cap on a navy background

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Vial size

$49.00

USD · 5 mg · In stock

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Order by 2:00 PM PT for same-day dispatch from Reno, Nevada. 1–3 business days by USPS Priority and UPS. Free shipping over $150.00.

For laboratory research use only. Not for human or veterinary use.

About the compound

Semaglutide is the most widely characterised long-acting GLP-1 receptor agonist. Its protease-resistant substitution and albumin-binding side chain make it a standard comparator in incretin research.

Supplied as a lyophilized powder in 5 mg and 10 mg vials.

Studied inGLP-1 receptor · Glucose homeostasis models · Receptor pharmacology

Certificate of analysis

The certificate for the lot currently shipping. Every vial in that lot carries the same lot number on its label.

Certificate of analysis

Semaglutide · 5 mg

Lot SN-SEM-2607 · tested Jul 25, 2026

99.38%

Purity by HPLC

Labeled: 5 mg
Measured: 5.1 mg
Panel: 6 passed · 2 reported
Laboratory: Independent ISO/IEC 17025 accredited laboratory

Assay	Method	Result	Outcome
Appearance	Visual	White lyophilized powder	Pass
Purity	HPLC · spec ≥ 98%	99.38%	Pass
Net peptide content	HPLC	5.1 mg	Reported
Identity	LC-MS	Confirmed	Pass
Heavy metals	ICP-MS	Not detected	Pass
Sterility	USP <71>	No growth	Pass
Endotoxin	LAL · USP <85>	< 0.05 EU/mL	Reported
Residual solvents	GC-HS	Within limits	Pass

Specification and storage

CAS number: 910463-68-2
Molecular formula: C187H291N45O59
Molecular weight: 4113.6 g/mol
Residues: 31
Sequence: H-His-Aib-Glu-Gly-Thr-Phe-Thr-Ser-Asp-Val-Ser-Ser-Tyr-Leu-Glu-Gly-Gln-Ala-Ala-Lys(γGlu-AEEA-AEEA-C18 diacid)-Glu-Phe-Ile-Ala-Trp-Leu-Val-Arg-Gly-Arg-Gly-OH
Reference record: PubChem entry

Storage

Sealed lyophilized vials are stable at room temperature for short periods; store at 2–8 °C for routine use.
For long-term storage keep sealed vials at −20 °C, protected from light and moisture.
Reconstituted solutions should be refrigerated at 2–8 °C and used within the period defined by your laboratory's protocol.

Literature

Peer-reviewed publications on this compound. Provided for reference; they are not claims about this product.

01
Journal of Medicinal Chemistry · 2015
Discovery of the Once-Weekly Glucagon-Like Peptide-1 (GLP-1) Analogue Semaglutide
Lau J, Bloch P, Schäffer L, et al.
02
The New England Journal of Medicine · 2016
Semaglutide and Cardiovascular Outcomes in Patients with Type 2 Diabetes
Marso SP, Bain SC, Consoli A, et al.
03
The New England Journal of Medicine · 2021
Once-Weekly Semaglutide in Adults with Overweight or Obesity
Wilding JPH, Batterham RL, Calanna S, et al.

Studied alongside

Tirzepatide
GIP / GLP-1 dual agonist
from $59.00
Cagrilintide
Long-acting amylin analogue
from $69.00

Research notice

Semaglutide is supplied for in vitro laboratory research and analytical use by qualified professionals. It is not a medicine, supplement or cosmetic, has not been evaluated by any regulator, and is not for human or veterinary use. Published findings cited on this page are provided for reference and are not claims about this product.